improve its safety,.e., using a purified/semi-purified bacteriocin preparation as an ingredient in food, by incorporating an ingredient previously fermented with a bacteriocin-producing strain,. Since techniques now available for the site-directed mutagenesis of bacteriocin structural genes (Kim et al, 1998) and with the help of genomics and proteomics, the possibility of constructing new families of designed peptides with enhanced antimicrobial activity or improved stability and specificity characteristics has become. Acidophilus ) isolated from Turkish dairy products showed inhibitory activity against Staphylococcus aureus, Escherichia coli and Yersinia enterocolitica due to bacteriocin-like substances. 1 with a small molecular weight, below 5 kDa (Gross and Morell, 1971). (2005 Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity.
A study made by Martinez and De Martinis (2005) has shown that at 8 C,. Range of activity Considering the antimicrobial spectrum, producing species, molecular weight, stability, physical-chemical properties and mode of action of bacteriocins, they form a heterogeneous group. In general, for the non-lantibiotic bacteriocins, the methods involve growth in a suitable liquid nutrient medium under optimal conditions for bacteriocin production, removal of the cells followed by fractionated precipitation of the proteins from the culture supernatant by addition of ammonium sulfate. NisI is thought to encode a lipoprotein involved in nisin immunity, and nisP appears to be involved in the regulation of nisin biosynthesis (Vandermeer et al, 1993). The spreading of bacterial antibiotic resistance and the demand for products with fewer chemicals create the necessity of exploring new alternatives, in order to reduce the abusive use of therapeutic antibiotics. 16 Haber was also active in the research on combustion reactions, the separation of gold from sea water, adsorption effects, electrochemistry, and free radical research (see Fenton's reagent ).